Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury

DNA double-strand breaks occur in many acute and long-term neurological conditions, including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically activate the DNA damage response in neurons, leading to neural dysfunction and apoptosis. Here, we show that targeting of the centr...

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Detalles Bibliográficos
Autores principales: Taylor, Matthew J., Thompson, Adam M., Alhajlah, Sharif, Tuxworth, Richard I., Ahmed, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473583/
https://www.ncbi.nlm.nih.gov/pubmed/36103534
http://dx.doi.org/10.1126/sciadv.abq2611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473583/
https://www.ncbi.nlm.nih.gov/pubmed/36103534
http://dx.doi.org/10.1126/sciadv.abq2611

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