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Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury
DNA double-strand breaks occur in many acute and long-term neurological conditions, including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically activate the DNA damage response in neurons, leading to neural dysfunction and apoptosis. Here, we show that targeting of the centr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473583/ https://www.ncbi.nlm.nih.gov/pubmed/36103534 http://dx.doi.org/10.1126/sciadv.abq2611 |