Exploring the misfolding and self-assembly mechanism of TTR (105–115) peptides by all-atom molecular dynamics simulation

Pathological aggregation of essentially dissociative Transthyretin (TTR) monomers protein, driven by misfolded and self-interaction, is connected with Amyloid Transthyretin amyloidosis (ATTR) disease. The TTR monomers protein contains several fragments that tend to self-aggregate, such as residue 10...

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Detalles Bibliográficos
Autores principales: Zhang, Yuqi, Zhu, Yanyan, Yue, Haiyan, Zhao, Qingjie, Li, Huiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473747/
https://www.ncbi.nlm.nih.gov/pubmed/36120541
http://dx.doi.org/10.3389/fmolb.2022.982276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473747/
https://www.ncbi.nlm.nih.gov/pubmed/36120541
http://dx.doi.org/10.3389/fmolb.2022.982276

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