Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity

Adaptive immunity depends on cell surface presentation of antigenic peptides by major histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in the secretory pathway. The chaperone tapasin in conjunction with the oxidoreductase ERp57 is crucial for MHC I assembly an...

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Detalles Bibliográficos
Autores principales: Müller, Ines Katharina, Winter, Christian, Thomas, Christoph, Spaapen, Robbert M., Trowitzsch, Simon, Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474470/
https://www.ncbi.nlm.nih.gov/pubmed/36104323
http://dx.doi.org/10.1038/s41467-022-32841-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474470/
https://www.ncbi.nlm.nih.gov/pubmed/36104323
http://dx.doi.org/10.1038/s41467-022-32841-9

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