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Cephem‐Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis

Tuberculosis (TB) is a leading source of infectious disease mortality globally. Antibiotic‐resistant strains comprise an estimated 10 % of new TB cases and present an urgent need for novel therapeutics. β‐lactam antibiotics have traditionally been ineffective against M. tuberculosis (Mtb), the causa...

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Detalles Bibliográficos
Autores principales: Cole, Malcolm S., Howe, Michael D., Buonomo, Joseph A., Sharma, Sachin, Lamont, Elise A., Brody, Scott I., Mishra, Neeraj K., Minato, Yusuke, Thiede, Joshua M., Baughn, Anthony D., Aldrich, Courtney C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474573/
https://www.ncbi.nlm.nih.gov/pubmed/35697660
http://dx.doi.org/10.1002/chem.202200995