Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1

PURPOSE: Bintrafusp alfa (BA) is a bifunctional fusion protein composed of the extracellular domain of the transforming growth factor-β (TGF-β) receptor II fused to a human immunoglobulin G1 antibody blocking programmed death ligand 1 (PD-L1). The recommended phase 2 dose (RP2D) was selected based o...

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Detalles Bibliográficos
Autores principales: Vugmeyster, Yulia, Grisic, Ana-Marija, Wilkins, Justin J., Loos, Anja H., Hallwachs, Roland, Osada, Motonobu, Venkatakrishnan, Karthik, Khandelwal, Akash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474582/
https://www.ncbi.nlm.nih.gov/pubmed/36066618
http://dx.doi.org/10.1007/s00280-022-04468-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474582/
https://www.ncbi.nlm.nih.gov/pubmed/36066618
http://dx.doi.org/10.1007/s00280-022-04468-6

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