Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas

Glial‐lineage malignancies (gliomas) recurrently mutate and/or delete the master regulators of apoptosis p53 and/or p16/CDKN2A, undermining apoptosis‐intending (cytotoxic) treatments. By contrast to disrupted p53/p16, glioma cells are live‐wired with the master transcription factor circuits that spe...

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Detalles Bibliográficos
Autores principales: von Knebel Doeberitz, Nikolaus, Paech, Daniel, Sturm, Dominik, Pusch, Stefan, Turcan, Sevin, Saunthararajah, Yogen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474618/
https://www.ncbi.nlm.nih.gov/pubmed/35603902
http://dx.doi.org/10.1002/ijc.34131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474618/
https://www.ncbi.nlm.nih.gov/pubmed/35603902
http://dx.doi.org/10.1002/ijc.34131

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