Confined migration induces heterochromatin formation and alters chromatin accessibility

During migration, cells often squeeze through small constrictions, requiring extensive deformation. We hypothesized that nuclear deformation associated with such confined migration could alter chromatin organization and function. By studying cells migrating through microfluidic devices that mimic in...

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Detalles Bibliográficos
Autores principales: Hsia, Chieh-Ren, McAllister, Jawuanna, Hasan, Ovais, Judd, Julius, Lee, Seoyeon, Agrawal, Richa, Chang, Chao-Yuan, Soloway, Paul, Lammerding, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474860/
https://www.ncbi.nlm.nih.gov/pubmed/36117991
http://dx.doi.org/10.1016/j.isci.2022.104978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474860/
https://www.ncbi.nlm.nih.gov/pubmed/36117991
http://dx.doi.org/10.1016/j.isci.2022.104978

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