SMAD3 contributes to ascending aortic dilatation independent of transforming growth factor-beta in bicuspid and unicuspid aortic valve disease

We sought to determine whether there are differences in transforming growth factor-beta (TGFß) signaling in aneurysms associated with bicuspid (BAV) and unicuspid (UAV) aortic valves versus normal aortic valves. Ascending aortic aneurysms are frequently associated with BAV and UAV. The mechanisms ar...

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Detalles Bibliográficos
Autores principales: Balint, Brittany, Federspiel, Jan, Kollmann, Catherine, Teping, Paul, Schwab, Tanja, Schäfers, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474869/
https://www.ncbi.nlm.nih.gov/pubmed/36104385
http://dx.doi.org/10.1038/s41598-022-19335-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474869/
https://www.ncbi.nlm.nih.gov/pubmed/36104385
http://dx.doi.org/10.1038/s41598-022-19335-w

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