Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice

Periodontitis is a highly prevalent disease leading to uncontrolled osteoclastic jawbone resorption and ultimately edentulism; however, the disease onset mechanism has not been fully elucidated. Here we propose a mechanism for initial pathology based on results obtained using a recently developed Os...

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Detalles Bibliográficos
Autores principales: Kondo, Takeru, Okawa, Hiroko, Hokugo, Akishige, Shokeen, Bhumika, Sundberg, Oskar, Zheng, Yiying, McKenna, Charles E., Lux, Renate, Nishimura, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474870/
https://www.ncbi.nlm.nih.gov/pubmed/36104423
http://dx.doi.org/10.1038/s42003-022-03896-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474870/
https://www.ncbi.nlm.nih.gov/pubmed/36104423
http://dx.doi.org/10.1038/s42003-022-03896-7

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