Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about...

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Detalles Bibliográficos
Autores principales: Fan, Xuejun, Yuan, Zihao, Zhao, Yueshui, Xiong, Wei, Hsiao, Hao-Ching, Pare, Rahmawati, Ding, Jianmin, Almosa, Ahmad, Sun, Kai, Zhang, Songlin, Jordan, Robert E., Lee, Cheok Song, An, Zhiqiang, Zhang, Ningyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474879/
https://www.ncbi.nlm.nih.gov/pubmed/36104515
http://dx.doi.org/10.1038/s42003-022-03931-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474879/
https://www.ncbi.nlm.nih.gov/pubmed/36104515
http://dx.doi.org/10.1038/s42003-022-03931-7

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