Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties

Cancer-associated fibroblasts (CAF) are a major cellular component of epithelial tumors. In breast cancers in particular these stromal cells have numerous tumorigenic effects in part due to their acquisition of a myofibroblastic phenotype. Breast CAFs (bCAFs) typically express MCL-1. We show here th...

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Detalles Bibliográficos
Autores principales: Bonneaud, Thomas L., Lefebvre, Chloé C., Nocquet, Lisa, Basseville, Agnes, Roul, Julie, Weber, Hugo, Campone, Mario, Juin, Philippe P., Souazé, Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474880/
https://www.ncbi.nlm.nih.gov/pubmed/36104324
http://dx.doi.org/10.1038/s41419-022-05214-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474880/
https://www.ncbi.nlm.nih.gov/pubmed/36104324
http://dx.doi.org/10.1038/s41419-022-05214-9

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