Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003

PURPOSE: PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG). PATIENTS AND METHODS: Patients (3–25 years) were enrolled on the basis of imaging consistent with DIPG. Biopsy tissue was collected for whole-exome a...

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Detalles Bibliográficos
Autores principales: Kline, Cassie, Jain, Payal, Kilburn, Lindsay, Bonner, Erin R., Gupta, Nalin, Crawford, John R., Banerjee, Anu, Packer, Roger J., Villanueva-Meyer, Javier, Luks, Tracy, Zhang, Yalan, Kambhampati, Madhuri, Zhang, Jie, Yadavilli, Sridevi, Zhang, Bo, Gaonkar, Krutika S., Rokita, Jo Lynne, Kraya, Adam, Kuhn, John, Liang, Winnie, Byron, Sara, Berens, Michael, Molinaro, Annette, Prados, Michael, Resnick, Adam, Waszak, Sebastian M., Nazarian, Javad, Mueller, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Clinical Trials: Targeted Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475246/
https://www.ncbi.nlm.nih.gov/pubmed/35852795
http://dx.doi.org/10.1158/1078-0432.CCR-22-0803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475246/
https://www.ncbi.nlm.nih.gov/pubmed/35852795
http://dx.doi.org/10.1158/1078-0432.CCR-22-0803

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