Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data

PURPOSE: Precise mechanism-based gene expression signatures (GES) have been developed in appropriate in vitro and in vivo model systems, to identify important cancer-related signaling processes. However, some GESs originally developed to represent specific disease processes, primarily with an epithe...

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Detalles Bibliográficos
Autores principales: Fisher, Natalie C., Byrne, Ryan M., Leslie, Holly, Wood, Colin, Legrini, Assya, Cameron, Andrew J., Ahmaderaghi, Baharak, Corry, Shania M., Malla, Sudhir B., Amirkhah, Raheleh, McCooey, Aoife J., Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, Domingo, Enric, Jackson, James, Loughrey, Maurice B., Leedham, Simon, Maughan, Tim, Lawler, Mark, Sansom, Owen J., Lamrock, Felicity, Koelzer, Viktor H., Jamieson, Nigel B., Dunne, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475248/
https://www.ncbi.nlm.nih.gov/pubmed/35792866
http://dx.doi.org/10.1158/1078-0432.CCR-22-1102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475248/
https://www.ncbi.nlm.nih.gov/pubmed/35792866
http://dx.doi.org/10.1158/1078-0432.CCR-22-1102

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