Cargando…

Large-Scale In Vitro and In Vivo CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia

PURPOSE: The molecular complexity of acute myeloid leukemia (AML) presents a considerable challenge to implementation of clinical genetic testing for accurate risk stratification. Identification of better biomarkers therefore remains a high priority to enable improving established stratification and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Peng, Jin, Qiqi, Wang, Xiaoling, Zhao, Ming, Dong, Fangyi, Jiang, Ge, Li, Zeyi, Shen, Jie, Zhang, Wei, Wu, Shishuang, Li, Ran, Zhang, Yunxiang, Li, Xiaoyang, Li, Junmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Precision Medicine and Imaging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475249/ https://www.ncbi.nlm.nih.gov/pubmed/35877119 http://dx.doi.org/10.1158/1078-0432.CCR-22-1618

Ejemplares similares

Development and Validation of a Novel Prognostic Model for Acute Myeloid Leukemia Based on Immune-Related Genes
por: Li, Ran, et al.
Publicado: (2021)

Identification and validation of a novel CD8+ T cell-associated prognostic model based on ferroptosis in acute myeloid leukemia
por: Jiang, Ge, et al.
Publicado: (2023)

92811 Implementation of the Fitness, Lifestyle, and Optimal Wellness (FLOW) Program and Its Associated Health Outcomes
por: Brake, Daniel, et al.
Publicado: (2021)

Immune‐relatedlncRNAs can predict the prognosis of acute myeloid leukemia
por: Li, Ran, et al.
Publicado: (2021)

CRISPR/Cas9‑mediated EZH2 knockout suppresses the proliferation and migration of triple‑negative breast cancer cells
por: Mao, Qiqi, et al.
Publicado: (2023)

Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages
por: Zhang, Shuzhong, et al.
Publicado: (2020)

CRISPR/Cas9-Mediated α-ENaC Knockout in a Murine Pancreatic β-Cell Line
por: Zhang, Xue, et al.
Publicado: (2021)

Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting
por: Li, Ze, et al.
Publicado: (2017)

Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system
por: Miao, Jinxin, et al.
Publicado: (2022)

CRISPR/Cas9 mediated chicken Stra8 gene knockout and inhibition of male germ cell differentiation
por: Zhang, Yani, et al.
Publicado: (2017)

CRISPR-Cas9-induced gene knockout in zebrafish
por: Medishetti, Raghavender, et al.
Publicado: (2022)

CRISPR/Cas9-induced knockout and knock-in mutations in Chlamydomonas reinhardtii
por: Shin, Sung-Eun, et al.
Publicado: (2016)

User-Friendly Genetic Conditional Knockout Strategies by CRISPR/Cas9
por: Chen, Liangliang, et al.
Publicado: (2018)

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
por: Hai, Tang, et al.
Publicado: (2014)

CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans
por: Au, Vinci, et al.
Publicado: (2018)

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9
por: Freund, Emily C., et al.
Publicado: (2020)

Optimized CRISPR/Cas9 system for gene knockout in chicken DF1 cells
por: Zou, Kexin, et al.
Publicado: (2023)

CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue
por: Jin, Jiankang, et al.
Publicado: (2020)

JACKS: joint analysis of CRISPR/Cas9 knockout screens
por: Allen, Felicity, et al.
Publicado: (2019)

Generation of Gene-Knockout Mongolian Gerbils via CRISPR/Cas9 System
por: Wang, Yan, et al.
Publicado: (2020)

Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated gluk2 Knockout in Zebrafish
por: Yan, Qianqian, et al.
Publicado: (2022)

Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
por: Zhang, Jinping, et al.
Publicado: (2023)

310 Mechanisms of progression of myelodysplastic syndrome to fatal secondary acute myeloid leukemia
por: Chang, Daniel, et al.
Publicado: (2023)

Establishment of a CRISPR/Cas9-Mediated Efficient Knockout System of Trichoderma hamatum T21 and Pigment Synthesis PKS Gene Knockout
por: Luo, Ning, et al.
Publicado: (2023)

NPM1A in Plasma is a Potential Prognostic Biomarker in Acute Myeloid Leukemia
por: Sun, Chengming, et al.
Publicado: (2018)

CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection
por: Sellaththurai, Sarithaa, et al.
Publicado: (2023)

Streamlined procedure for gene knockouts using all-in-one adenoviral CRISPR-Cas9
por: Jin, Yuan-Hu, et al.
Publicado: (2019)

DNA-free two-gene knockout in Chlamydomonas reinhardtii via CRISPR-Cas9 ribonucleoproteins
por: Baek, Kwangryul, et al.
Publicado: (2016)

CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
por: Lee, HyunJeong, et al.
Publicado: (2018)

Site-Directed Genome Knockout in Chicken Cell Line and Embryos Can Use CRISPR/Cas Gene Editing Technology
por: Zuo, Qisheng, et al.
Publicado: (2016)

Epidemiology of Febrile Neutropenia Episodes with Gram-Negative Bacteria Infection in Patients Who Have Undergone Chemotherapy for Hematologic Malignancies: A Retrospective Study of 10 Years' Data from a Single Center
por: Zhang, Yunxiang, et al.
Publicado: (2020)

Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance
por: Cao, Jie, et al.
Publicado: (2018)

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells
por: Kim, Hyeung, et al.
Publicado: (2017)

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System
por: Ni, Wei, et al.
Publicado: (2014)

CRISPR/Cas9-mediated gene knockout in the ascidian Ciona intestinalis
por: Sasaki, Haruka, et al.
Publicado: (2014)

Simplified Gene Knockout by CRISPR-Cas9-Induced Homologous Recombination
por: Dalvie, Neil C., et al.
Publicado: (2021)

CRISPR-Cas knockout of miR21 reduces glioma growth
por: Nieland, Lisa, et al.
Publicado: (2022)

An efficient and precise method for generating knockout cell lines based on CRISPR‐Cas9 system
por: Lu, Xibin, et al.
Publicado: (2020)

RPA-CRISPR/Cas12a-Based Detection of Haemophilus parasuis
por: Zhang, Kunli, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i3f040lrukgpec2ggvapaioglg