Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease

Mutant huntingtin, which causes Huntington’s disease (HD), is ubiquitously expressed but induces preferential loss of striatal neurons by unclear mechanisms. Rab11 dysfunction mediates homeostatic disturbance of HD neurons. Here, we report that Rab11 dysfunction also underscores the striatal vulnera...

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Detalles Bibliográficos
Autores principales: Chhetri, Gaurav, Ke, Yuting, Wang, Ping, Usman, Muhammad, Li, Yan, Sapp, Ellen, Wang, Jing, Ghosh, Arabinda, Islam, Md Ariful, Wang, Xiaolong, Boudi, Adel, DiFiglia, Marian, Li, Xueyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475296/
https://www.ncbi.nlm.nih.gov/pubmed/36099524
http://dx.doi.org/10.1083/jcb.202112073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475296/
https://www.ncbi.nlm.nih.gov/pubmed/36099524
http://dx.doi.org/10.1083/jcb.202112073

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