What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake

The aim of this study was to investigate the effect of replacing Glu in the Lys-urea-Glu PSMA-targeting pharmacophore of [(68)Ga]Ga-HTK03041 with a close analog on the uptake of kidneys, salivary glands and PSMA-expressing tumor xenografts. Methods: HTK03161, HTK03149 and HTK03189A/B were obtained b...

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Detalles Bibliográficos
Autores principales: Kuo, Hsiou-Ting, Lin, Kuo-Shyan, Zhang, Zhengxing, Zhang, Chengcheng, Merkens, Helen, Tan, Ruiyan, Roxin, Aron, Uribe, Carlos F., Bénard, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475448/
https://www.ncbi.nlm.nih.gov/pubmed/36168623
http://dx.doi.org/10.7150/thno.76571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475448/
https://www.ncbi.nlm.nih.gov/pubmed/36168623
http://dx.doi.org/10.7150/thno.76571

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