Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization

Macrophage polarization is a process whereby macrophages acquire distinct effector states (M1 or M2) to carry out multiple and sometimes opposite functions. We show here that translational reprogramming occurs during macrophage polarization and that this relies on the Elongator complex subunit Elp3,...

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Detalles Bibliográficos
Autores principales: Chen, Dawei, Nemazanyy, Ivan, Peulen, Olivier, Shostak, Kateryna, Xu, Xinyi, Tang, Seng Chuan, Wathieu, Caroline, Turchetto, Silvia, Tielens, Sylvia, Nguyen, Laurent, Close, Pierre, Desmet, Christophe, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Petrellis, Georgios, Dewals, Benjamin, Chariot, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475509/
https://www.ncbi.nlm.nih.gov/pubmed/35920020
http://dx.doi.org/10.15252/embj.2021109353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475509/
https://www.ncbi.nlm.nih.gov/pubmed/35920020
http://dx.doi.org/10.15252/embj.2021109353

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