Pioneer Factor Improves CRISPR‐Based C‐To‐G and C‐To‐T Base Editing

Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer factors, the authors found that SOX2 substantially increased...

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Detalles Bibliográficos
Autores principales: Yang, Chao, Dong, Xingxiao, Ma, Zhenzhen, Li, Bo, Bi, Changhao, Zhang, Xueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475549/
https://www.ncbi.nlm.nih.gov/pubmed/35861371
http://dx.doi.org/10.1002/advs.202202957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475549/
https://www.ncbi.nlm.nih.gov/pubmed/35861371
http://dx.doi.org/10.1002/advs.202202957

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