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Pioneer Factor Improves CRISPR‐Based C‐To‐G and C‐To‐T Base Editing
Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer factors, the authors found that SOX2 substantially increased...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475549/ https://www.ncbi.nlm.nih.gov/pubmed/35861371 http://dx.doi.org/10.1002/advs.202202957 |