Low-level whole-brain radiation enhances theranostic potential of single-domain antibody fragments for human epidermal growth factor receptor type 2 (HER2)-positive brain metastases

BACKGROUND: Single-domain antibody fragments (aka V(H)H, ~ 13 kDa) are promising delivery systems for brain tumor theranostics; however, achieving efficient delivery of V(H)H to intracranial lesions remains challenging due to the tumor–brain barrier. Here, we evaluate low-dose whole-brain irradiatio...

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Detalles Bibliográficos
Autores principales: Procissi, Daniele, Jannetti, Stephen A, Zannikou, Markella, Zhou, Zhengyuan, McDougald, Darryl, Kanojia, Deepak, Zhang, Hui, Burdett, Kirsten, Vaidyanathan, Ganesan, Zalutsky, Michael R, Balyasnikova, Irina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476215/
https://www.ncbi.nlm.nih.gov/pubmed/36128586
http://dx.doi.org/10.1093/noajnl/vdac135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476215/
https://www.ncbi.nlm.nih.gov/pubmed/36128586
http://dx.doi.org/10.1093/noajnl/vdac135

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