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Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function

Large-scale genomic studies of schizophrenia implicate genes involved in the epigenetic regulation of transcription by histone methylation and genes encoding components of the synapse. However, the interactions between these pathways in conferring risk to psychiatric illness are unknown. Loss-of-fun...

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Detalles Bibliográficos
Autores principales: Clifton, Nicholas E, Bosworth, Matthew L, Haan, Niels, Rees, Elliott, Holmans, Peter A, Wilkinson, Lawrence S, Isles, Anthony R, Collins, Mark O, Hall, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476630/
https://www.ncbi.nlm.nih.gov/pubmed/35531971
http://dx.doi.org/10.1093/hmg/ddac105