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Gene mining and efficient biosynthesis of a fungal peptidyl alkaloid

OBJECTIVE: Peptidyl alkaloids, a series of important natural products can be assembled by fungal non-ribosomal peptide synthetases (NRPSs). However, many of the NRPSs associated gene clusters are silent under laboratory conditions, and the traditional chemical separation yields are low. In this stud...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Liu, Bing-yu, Liu, Jia-wang, Yan, Dao-jiang, Bai, Jian, Zhang, Ya-long, Mou, Yan-hua, Hu, You-cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476675/
https://www.ncbi.nlm.nih.gov/pubmed/36117764
http://dx.doi.org/10.1016/j.chmed.2020.11.003