Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy

Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively and predispose patients to hereditary cancer syndromes including the development of aggressive renal cell carcino...

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Detalles Bibliográficos
Autores principales: Ueno, Daiki, Vasquez, Juan C., Sule, Amrita, Liang, Jiayu, van Doorn, Jinny, Sundaram, Ranjini, Friedman, Sam, Caliliw, Randy, Ohtake, Shinji, Bao, Xun, Li, Jing, Ye, Huihui, Boyd, Karla, Huang, Rong Rong, Dodson, Jack, Boutros, Paul, Bindra, Ranjit S., Shuch, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477221/
https://www.ncbi.nlm.nih.gov/pubmed/36128328
http://dx.doi.org/10.18632/oncotarget.28273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477221/
https://www.ncbi.nlm.nih.gov/pubmed/36128328
http://dx.doi.org/10.18632/oncotarget.28273

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