FRA1:c-JUN:HDAC1 complex down-regulates filaggrin expression upon TNFα and IFNγ stimulation in keratinocytes

Filaggrin (FLG), an essential structural protein for skin barrier function, is down-regulated under chronic inflammatory conditions, leading to disruption of the skin barrier. However, the detailed molecular mechanisms of how FLG changes in the context of chronic inflammation are poorly understood....

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Detalles Bibliográficos
Autores principales: Ahn, Sung Shin, Yeo, Hyunjin, Jung, Euitaek, Lim, Yoongho, Lee, Young Han, Shin, Soon Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477237/
https://www.ncbi.nlm.nih.gov/pubmed/36067301
http://dx.doi.org/10.1073/pnas.2123451119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477237/
https://www.ncbi.nlm.nih.gov/pubmed/36067301
http://dx.doi.org/10.1073/pnas.2123451119

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