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Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM

The Tetrahymena group I intron has been a key system in the understanding of RNA folding and misfolding. The molecule folds into a long-lived misfolded intermediate (M) in vitro, which has been known to form extensive native-like secondary and tertiary structures but is separated by an unknown kinet...

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Detalles Bibliográficos
Autores principales: Li, Shanshan, Palo, Michael Z., Pintilie, Grigore, Zhang, Xiaojing, Su, Zhaoming, Kappel, Kalli, Chiu, Wah, Zhang, Kaiming, Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477386/
https://www.ncbi.nlm.nih.gov/pubmed/36067294
http://dx.doi.org/10.1073/pnas.2209146119