Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10, VRC42.01 and PGZL1, can neutralize >80% of viruses. These three MPER-directed monoclonal antibodies share germline antibody genes (IGHV1-69 and IGKV3-20) and form a...

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Detalles Bibliográficos
Autores principales: Scheepers, Cathrine, Kgagudi, Prudence, Mzindle, Nonkululeko, Gray, Elin S., Moyo-Gwete, Thandeka, Lambson, Bronwen E., Oosthuysen, Brent, Mabvakure, Batsirai, Garrett, Nigel J., Abdool Karim, Salim S., Morris, Lynn, Moore, Penny L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477419/
https://www.ncbi.nlm.nih.gov/pubmed/36054228
http://dx.doi.org/10.1371/journal.ppat.1010450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477419/
https://www.ncbi.nlm.nih.gov/pubmed/36054228
http://dx.doi.org/10.1371/journal.ppat.1010450

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