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Repair of mismatched templates during Rad51-dependent Break-Induced Replication

Using budding yeast, we have studied Rad51-dependent break-induced replication (BIR), where the invading 3’ end of a site-specific double-strand break (DSB) and a donor template share 108 bp of homology that can be easily altered. BIR still occurs about 10% as often when every 6(th) base is mismatch...

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Detalles Bibliográficos
Autores principales: Choi, Jihyun, Kong, Muwen, Gallagher, Danielle N., Li, Kevin, Bronk, Gabriel, Cao, Yiting, Greene, Eric C., Haber, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477423/
https://www.ncbi.nlm.nih.gov/pubmed/36054210
http://dx.doi.org/10.1371/journal.pgen.1010056