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Identifying cellular cancer mechanisms through pathway-driven data integration

MOTIVATION: Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those most internally perturbed by gene expression changes. However, driver genes c...

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Detalles Bibliográficos
Autores principales: Windels, Sam F L, Malod-Dognin, Noël, Pržulj, Nataša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477533/
https://www.ncbi.nlm.nih.gov/pubmed/35916710
http://dx.doi.org/10.1093/bioinformatics/btac493