Overcoming selection bias in synthetic lethality prediction

MOTIVATION: Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaus...

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Detalles Bibliográficos
Autores principales: Seale, Colm, Tepeli, Yasin, Gonçalves, Joana P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477536/
https://www.ncbi.nlm.nih.gov/pubmed/35876858
http://dx.doi.org/10.1093/bioinformatics/btac523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477536/
https://www.ncbi.nlm.nih.gov/pubmed/35876858
http://dx.doi.org/10.1093/bioinformatics/btac523

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