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Overcoming selection bias in synthetic lethality prediction

MOTIVATION: Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaus...

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Detalles Bibliográficos
Autores principales:	Seale, Colm, Tepeli, Yasin, Gonçalves, Joana P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477536/ https://www.ncbi.nlm.nih.gov/pubmed/35876858 http://dx.doi.org/10.1093/bioinformatics/btac523

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