Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation
CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80 and CD86, the specific requirement for two distinct ligands remains obscure. In the present stud...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477731/ https://www.ncbi.nlm.nih.gov/pubmed/35999394 http://dx.doi.org/10.1038/s41590-022-01289-w |