Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination

T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens. According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstre...

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Detalles Bibliográficos
Autores principales: Voisinne, Guillaume, Locard-Paulet, Marie, Froment, Carine, Maturin, Emilie, Menoita, Marisa Goncalves, Girard, Laura, Mellado, Valentin, Burlet-Schiltz, Odile, Malissen, Bernard, Gonzalez de Peredo, Anne, Roncagalli, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477740/
https://www.ncbi.nlm.nih.gov/pubmed/36045187
http://dx.doi.org/10.1038/s41590-022-01288-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477740/
https://www.ncbi.nlm.nih.gov/pubmed/36045187
http://dx.doi.org/10.1038/s41590-022-01288-x

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