Cargando…
Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination
T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens. According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstre...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477740/ https://www.ncbi.nlm.nih.gov/pubmed/36045187 http://dx.doi.org/10.1038/s41590-022-01288-x |