Structure of the active G(i)-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist

Lysophosphatidic acid receptor 1 (LPA(1)) is one of the six G protein-coupled receptors activated by the bioactive lipid, lysophosphatidic acid (LPA). LPA(1) is a drug target for various diseases, including cancer, inflammation, and neuropathic pain. Notably, LPA(1) agonists have potential therapeut...

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Detalles Bibliográficos
Autores principales: Akasaka, Hiroaki, Tanaka, Tatsuki, Sano, Fumiya K., Matsuzaki, Yuma, Shihoya, Wataru, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477835/
https://www.ncbi.nlm.nih.gov/pubmed/36109516
http://dx.doi.org/10.1038/s41467-022-33121-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477835/
https://www.ncbi.nlm.nih.gov/pubmed/36109516
http://dx.doi.org/10.1038/s41467-022-33121-2

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