GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice

A newly deorphanized G protein-coupled receptor, GPR171, is found to be highly expressed within the periaqueductal gray, a pain-modulating region in the brain. Our recent research has shown that a GPR171 agonist increases morphine antinociception in male mice and opioid signaling in vitro. The objec...

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Detalles Bibliográficos
Autores principales: Afrose, Leela, McDermott, Max V., Bhuiyan, Ashif I., Pathak, Sanjai K., Bobeck, Erin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477863/
https://www.ncbi.nlm.nih.gov/pubmed/35942845
http://dx.doi.org/10.1097/FBP.0000000000000692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477863/
https://www.ncbi.nlm.nih.gov/pubmed/35942845
http://dx.doi.org/10.1097/FBP.0000000000000692

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