Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems

Of the 10 paralogs of MazEF Toxin-Antitoxin system in Mycobacterium tuberculosis, MazEF6 plays an important role in multidrug tolerance, virulence, stress adaptation and Non Replicative Persistant (NRP) state establishment. The solution structures of the DNA binding domain of MazE6 and of its comple...

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Detalles Bibliográficos
Autores principales: Kumari, Khushboo, Sarma, Siddhartha P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477884/
https://www.ncbi.nlm.nih.gov/pubmed/36109664
http://dx.doi.org/10.1038/s42003-022-03933-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477884/
https://www.ncbi.nlm.nih.gov/pubmed/36109664
http://dx.doi.org/10.1038/s42003-022-03933-5

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