Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes

AIMS/HYPOTHESIS: The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With ageing, DNA methylation of FHL2 increases, as well as expression of the four and a half LIM domains 2 (FHL2) protein in human pancreatic islets. We hypothesised that F...

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Detalles Bibliográficos
Autores principales: Habibe, Jayron J., Clemente-Olivo, Maria P., Scheithauer, Torsten P. M., Rampanelli, Elena, Herrema, Hilde, Vos, Mariska, Mieremet, Arnout, Nieuwdorp, Max, van Raalte, Daniel H., Eringa, Etto C., de Vries, Carlie J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477948/
https://www.ncbi.nlm.nih.gov/pubmed/35802167
http://dx.doi.org/10.1007/s00125-022-05750-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477948/
https://www.ncbi.nlm.nih.gov/pubmed/35802167
http://dx.doi.org/10.1007/s00125-022-05750-1

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