Targeting Histone Demethylase LSD1 for Treatment of Deficits in Autism Mouse Models

Large-scale genetic studies have revealed that the most prominent genes disrupted in autism are chromatin regulators mediating histone methylation/demethylation, suggesting the central role of epigenetic dysfunction in this disorder. Here, we show that histone lysine 4 dimethylation (H3K4me2), a his...

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Detalles Bibliográficos
Autores principales: Rapanelli, Maximiliano, Williams, Jamal B., Ma, Kaijie, Yang, Fengwei, Zhong, Ping, Patel, Rajvi, Kumar, Manasa, Qin, Luye, Rein, Benjamin, Wang, Zi-Jun, Kassim, Bibi, Javidfar, Behnam, Couto, Lizette, Akbarian, Schahram, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477974/
https://www.ncbi.nlm.nih.gov/pubmed/35296809
http://dx.doi.org/10.1038/s41380-022-01508-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477974/
https://www.ncbi.nlm.nih.gov/pubmed/35296809
http://dx.doi.org/10.1038/s41380-022-01508-8

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