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Targeting Histone Demethylase LSD1 for Treatment of Deficits in Autism Mouse Models
Large-scale genetic studies have revealed that the most prominent genes disrupted in autism are chromatin regulators mediating histone methylation/demethylation, suggesting the central role of epigenetic dysfunction in this disorder. Here, we show that histone lysine 4 dimethylation (H3K4me2), a his...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477974/ https://www.ncbi.nlm.nih.gov/pubmed/35296809 http://dx.doi.org/10.1038/s41380-022-01508-8 |