Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase

Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells. A recent stud...

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Detalles Bibliográficos
Autores principales: Lazcano, Pablo, Schmidtke, Michael W., Onu, Chisom J., Greenberg, Miriam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478396/
https://www.ncbi.nlm.nih.gov/pubmed/35963434
http://dx.doi.org/10.1016/j.jbc.2022.102363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478396/
https://www.ncbi.nlm.nih.gov/pubmed/35963434
http://dx.doi.org/10.1016/j.jbc.2022.102363

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