Central residues in prion protein PrP(C) are crucial for its conversion into the pathogenic isoform

Conformational conversion of the cellular prion protein, PrP(C), into the amyloidogenic isoform, PrP(Sc), is a key pathogenic event in prion diseases. However, the conversion mechanism remains to be elucidated. Here, we generated Tg(PrPΔ91-106)-8545/Prnp(0/0) mice, which overexpress mouse PrP lackin...

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Detalles Bibliográficos
Autores principales: Pasiana, Agriani Dini, Miyata, Hironori, Chida, Junji, Hara, Hideyuki, Imamura, Morikazu, Atarashi, Ryuichiro, Sakaguchi, Suehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478402/
https://www.ncbi.nlm.nih.gov/pubmed/35973512
http://dx.doi.org/10.1016/j.jbc.2022.102381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478402/
https://www.ncbi.nlm.nih.gov/pubmed/35973512
http://dx.doi.org/10.1016/j.jbc.2022.102381

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