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Central residues in prion protein PrP(C) are crucial for its conversion into the pathogenic isoform
Conformational conversion of the cellular prion protein, PrP(C), into the amyloidogenic isoform, PrP(Sc), is a key pathogenic event in prion diseases. However, the conversion mechanism remains to be elucidated. Here, we generated Tg(PrPΔ91-106)-8545/Prnp(0/0) mice, which overexpress mouse PrP lackin...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478402/ https://www.ncbi.nlm.nih.gov/pubmed/35973512 http://dx.doi.org/10.1016/j.jbc.2022.102381 |