PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma

Cancer immunotherapy restores or enhances the effector function of T cells in the tumor microenvironment, but the efficacy of immunotherapy has been hindered by therapeutic resistance. Here, we identify the proto-oncogene serine/threonine protein kinase PIM2 as a novel negative feedback regulator of...

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Detalles Bibliográficos
Autores principales: Wang, Jun-Cheng, Chen, Dong-Ping, Lu, Shi-Xun, Chen, Jin-Bin, Wei, Yuan, Liu, Xue-Chao, Tang, Yu-Hao, Zhang, Rongxin, Chen, Jian-Cong, Kan, Anna, Xu, Li, Zhang, Yao-Jun, Hou, Jiajie, Kuang, Dong-Ming, Chen, Min-Shan, Zhou, Zhong-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478531/
https://www.ncbi.nlm.nih.gov/pubmed/35802648
http://dx.doi.org/10.1158/0008-5472.CAN-21-3899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478531/
https://www.ncbi.nlm.nih.gov/pubmed/35802648
http://dx.doi.org/10.1158/0008-5472.CAN-21-3899

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