Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility

Cancer-associated fibroblasts (CAFs) play an active role in remodeling the local tumor stroma to support tumor initiation, growth, invasion, metastasis, and therapeutic resistance. The CAF-secreted chemokine, CXCL12, has been directly implicated in the tumorigenic progression of carcinomas, includin...

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Detalles Bibliográficos
Autores principales: Holter, Jacob C., Chang, Chia-Wen, Avendano, Alex, Garg, Ayush A., Verma, Ajeet K., Charan, Manish, Ahirwar, Dinesh K., Ganju, Ramesh K., Song, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478647/
https://www.ncbi.nlm.nih.gov/pubmed/36118583
http://dx.doi.org/10.3389/fbioe.2022.888431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478647/
https://www.ncbi.nlm.nih.gov/pubmed/36118583
http://dx.doi.org/10.3389/fbioe.2022.888431

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