PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer’s disease

Disrupted tau proteostasis and transneuronal spread is a pathological hallmark of Alzheimer’s disease. Neurodegenerative diseases remain an unmet medical need and novel disease modifying therapeutics are paramount. Our objective was to develop a mechanistic mathematical model to enhance our understa...

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Detalles Bibliográficos
Autores principales: Bloomingdale, Peter, Bumbaca-Yadav, Daniela, Sugam, Jonathan, Grauer, Steve, Smith, Brad, Antonenko, Svetlana, Judo, Michael, Azadi, Glareh, Yee, Ka Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478891/
https://www.ncbi.nlm.nih.gov/pubmed/36120380
http://dx.doi.org/10.3389/fphar.2022.867457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478891/
https://www.ncbi.nlm.nih.gov/pubmed/36120380
http://dx.doi.org/10.3389/fphar.2022.867457

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