Cargando…

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways

Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or mutations affecting the B-cell transcription factor IK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Butler, Miriam, Vervoort, Britt M.T., van Ingen Schenau, Dorette S., Jongeneel, Lieneke, van der Zwet, Jordy C.G., Marke, René, Meijerink, Jules P.P., Scheijen, Blanca, van der Meer, Laurens T., van Leeuwen, Frank N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478899/ https://www.ncbi.nlm.nih.gov/pubmed/36119546 http://dx.doi.org/10.3389/fonc.2022.905665

Ejemplares similares

The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
por: Marke, René, et al.
Publicado: (2018)

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients
por: Scheijen, Blanca, et al.
Publicado: (2017)

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton
por: Tijchon, Esther, et al.
Publicado: (2015)

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway
por: Butler, Miriam, et al.
Publicado: (2021)

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress
por: Yuniati, Laurensia, et al.
Publicado: (2015)

Tumor suppressors BTG1 and BTG2: Beyond growth control
por: Yuniati, Laurensia, et al.
Publicado: (2018)

STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL and BCLXL following glucocorticoid treatment
por: van der Zwet, Jordy C.G., et al.
Publicado: (2022)

Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia Patients
por: van der Zwet, Jordy C. G., et al.
Publicado: (2020)

PB2391: FREQUENCY OF IKZF3 MUTATION IN WALDENSTRÖM’S MACROGLOBULINEMIA
por: Taleb, Assia, et al.
Publicado: (2023)

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution
por: Waanders, Esmé, et al.
Publicado: (2012)

Lenalidomide induces degradation of IKZF1 and IKZF3
por: Krönke, Jan, et al.
Publicado: (2014)

Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease
por: van der Burgh, Robert, et al.
Publicado: (2016)

Human CD34(+)-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8(+) T cell and NK cell responses in vitro and in vivo
por: van Eck van der Sluijs, Jesper, et al.
Publicado: (2023)

Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
por: van der Sligte, Naomi E, et al.
Publicado: (2015)

Baicalein Inhibits Proliferation of Myeloma U266 Cells by Downregulating IKZF1 and IKZF3
por: Liu, Xiao-Ping, et al.
Publicado: (2018)

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3–6 microdeletion
por: Venn, N C, et al.
Publicado: (2012)

Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives
por: Vandewalle, Julie, et al.
Publicado: (2021)

Molecular mechanisms contributing to glucocorticoid resistance in lymphoid malignancies
por: Scheijen, Blanca
Publicado: (2019)

Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
por: Woess, Katharina, et al.
Publicado: (2022)

Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide
por: Abdulkarim, Haya, et al.
Publicado: (2020)

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion
por: van der Burgh, Robert, et al.
Publicado: (2014)

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia
por: Østergaard, Anna, et al.
Publicado: (2023)

Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia
por: Pedersen, Susanne K., et al.
Publicado: (2015)

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus
por: Vyse, Timothy J., et al.
Publicado: (2020)

Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents
por: Ne, Enrico, et al.
Publicado: (2022)

The clinical impact of IKZF1 mutation in acute myeloid leukemia
por: Zhang, Xiang, et al.
Publicado: (2023)

Comparing Perimenstrual and Nonperimenstrual Migraine Attacks Using an e-Diary
por: van Casteren, Daphne S., et al.
Publicado: (2021)

Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1
por: Sriaroon, Panida, et al.
Publicado: (2019)

The specific distribution pattern of IKZF1 mutation in acute myeloid leukemia
por: Zhang, Xiang, et al.
Publicado: (2020)

Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation
por: Shahin, Tala, et al.
Publicado: (2022)

Detection of Pathogenic Isoforms of IKZF1 in Leukemic Cell Lines and Acute Lymphoblastic Leukemia Samples: Identification of a Novel Truncated IKZF1 Transcript in SUP-B15
por: Zhao, Weiqiang, et al.
Publicado: (2020)

Non-tuberculous mycobacterial lung disease in patients with bronchiectasis: perceived risk, severity and guideline adherence in a European physician survey
por: Wagner, Dirk, et al.
Publicado: (2020)

Global survey of physician testing practices for nontuberculous mycobacteria
por: Loebinger, Michael R., et al.
Publicado: (2023)

A machine learning approach to small area estimation: predicting the health, housing and well-being of the population of Netherlands
por: Viljanen, Markus, et al.
Publicado: (2022)

Methylation and Gene Expression of BCAT1 and IKZF1 in Colorectal Cancer Tissues
por: Jedi, Maher, et al.
Publicado: (2018)

Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes
por: Li, Zhen, et al.
Publicado: (2018)

Pathogenic germline IKZF1 variant alters hematopoietic gene expression profiles
por: Brodie, Seth A., et al.
Publicado: (2021)

Impact of IKZF1 Deletions in the Prognosis of Childhood Acute Lymphoblastic Leukemia in Argentina
por: Felice, María Sara, et al.
Publicado: (2022)

P322: DECIPHERING THE UNDERLYING MOLECULAR COMPLEXITY OF THE IKZF1PLUS SIGNATURE
por: Lühmann, Jonathan, et al.
Publicado: (2023)

Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia
por: Eckardt, Jan-Niklas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7qh5h758uolnmss84fagu6s4us