Cargando…

Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl

G protein–coupled receptors can signal through both G proteins and ß-arrestin2. For the µ-opioid receptor (MOR), early experimental evidence from a single study suggested that G protein signaling mediates analgesia and sedation, whereas ß-arrestin signaling mediates respiratory depression and consti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Xiangyun, Zhang, Junjie, Wang, Shaowen, Gao, Huan, Sun, Yi, Liu, Xiaoqian, Fu, Wei, Tan, Bo, Su, Ruibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478952/ https://www.ncbi.nlm.nih.gov/pubmed/36120357 http://dx.doi.org/10.3389/fphar.2022.919325

Ejemplares similares

Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids
por: Solimini, Renata, et al.
Publicado: (2018)

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy
por: Olson, Keith M., et al.
Publicado: (2023)

Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
por: Ugur, Muzeyyen, et al.
Publicado: (2018)

Functional selectivity of EM-2 analogs at the mu-opioid receptor
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2023)

Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
por: Lipiński, Piotr F. J., et al.
Publicado: (2019)

Transition From Full Mu Opioid Agonists to Buprenorphine in Opioid Dependent Patients—A Critical Review
por: Soyka, Michael
Publicado: (2021)

It’s MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system
por: Chartoff, Elena H., et al.
Publicado: (2014)

In vitro interaction between Ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects
por: Simoens, C, et al.
Publicado: (2003)

In Vitro Effects of Ligand Bias on Primate Mu Opioid Receptor Downstream Signaling
por: Zhang, Xiao, et al.
Publicado: (2020)

Effectiveness of Prophylactic Use of Hepatoprotectants for Tuberculosis Drug-Induced Liver Injury: A Population-Based Cohort Analysis Involving 6,743 Chinese Patients
por: Chen, Qin, et al.
Publicado: (2022)

Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells
por: Zhang, Xutong, et al.
Publicado: (2023)

Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective
por: Zhang, Li, et al.
Publicado: (2020)

Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
por: Erba, E, et al.
Publicado: (2000)

Structure-Based Approach for the Prediction of Mu-opioid Binding Affinity of Unclassified Designer Fentanyl-Like Molecules
por: Floresta, Giuseppe, et al.
Publicado: (2019)

Mechanism and Management of Fentanyl-Induced Cough
por: Chen, Rong, et al.
Publicado: (2020)

Upregulation of Hallmark Muscle Genes Protects Gne(M743T/M743T) Mutated Knock-In Mice From Kidney and Muscle Phenotype
por: Benyamini, Hadar, et al.
Publicado: (2020)

Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons – Effects of Nerve Injury
por: Stötzner, Philip, et al.
Publicado: (2018)

Opioid and GABA(B) receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment
por: Bagley, Elena E.
Publicado: (2014)

Context-sensitive half-time of fentanyl in dogs
por: IIZUKA, Tomoya, et al.
Publicado: (2015)

Metabolic Pathways and Potencies of New Fentanyl Analogs
por: Wilde, Maurice, et al.
Publicado: (2019)

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966
por: Reichenbach, Zachary W., et al.
Publicado: (2022)

Opioid Crisis—An Emphasis on Fentanyl Analogs
por: Lutfy, Kabirullah
Publicado: (2020)

European Drug Users at Risk from Illicit Fentanyls Mix
por: Pichini, Simona, et al.
Publicado: (2017)

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
por: Baby, Santhosh, et al.
Publicado: (2021)

“Tranq-dope” overdose and mortality: lethality induced by fentanyl and xylazine
por: Smith, Mark A., et al.
Publicado: (2023)

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice
por: Lattanzi, Roberta, et al.
Publicado: (2018)

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level
por: Moss, Ronald B., et al.
Publicado: (2020)

Predicting Transdermal Fentanyl Delivery Using Mechanistic Simulations for Tailored Therapy
por: Defraeye, Thijs, et al.
Publicado: (2020)

PT743. Mental Health status of Correctional Officers in Correctional Institutions
por: Park, Jong-Ik, et al.
Publicado: (2016)

743 Virtual burn care - friend or foe? A systematic review
por: Malic, Claudia, et al.
Publicado: (2022)

743 Educate Before You Operate: Improving the Informed Consent Process
por: Piatkowski, Brian, et al.
Publicado: (2023)

P743: CLINICAL OUTCOMES OF PATIENTS WITH MYELODYSPLASTIC SYNDROME AND SPLICEOSOME MUTATIONS
por: Urrutia, Samuel, et al.
Publicado: (2023)

Correction: Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level
Publicado: (2020)

Impact of Morphine Dependence and Withdrawal on the Reinforcing Effectiveness of Fentanyl, Cocaine, and Methamphetamine in Rats
por: Seaman Jr, Robert W., et al.
Publicado: (2021)

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
por: Vicario, Nunzio, et al.
Publicado: (2022)

How μ-Opioid Receptor Recognizes Fentanyl
por: Vo, Quynh N., et al.
Publicado: (2020)

How μ-Opioid Receptor Recognizes Fentanyl
por: Vo, Quynh N., et al.
Publicado: (2020)

How μ-opioid receptor recognizes fentanyl
por: Vo, Quynh N., et al.
Publicado: (2021)

Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics
por: Lipiński, Piotr F. J., et al.
Publicado: (2022)

Editorial: Opioids and opioid-use disorders
por: de Guglielmo, Giordano, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rq91ekrcbro9vnkj6v622gcgt7