Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA

[Image: see text] Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity chromatography using a methyl binding domain-2 (MBD2) protein can be used, but the relatively low enrichment selectivity of...

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Detalles Bibliográficos
Autores principales: Kolkman, Ruben W., Michel-Souzy, Sandra, Wasserberg, Dorothee, Segerink, Loes I., Huskens, Jurriaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478954/
https://www.ncbi.nlm.nih.gov/pubmed/36052432
http://dx.doi.org/10.1021/acsami.2c09641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478954/
https://www.ncbi.nlm.nih.gov/pubmed/36052432
http://dx.doi.org/10.1021/acsami.2c09641

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