Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) are involved in modulating cholinergic signaling, but their roles in Alzheimer’s and Parkinson’s diseases (AD and PD) remain unclear. We identified a higher frequency of the functionally impaired BCHE-K variant (rs1803274) in AD and PD c...

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Detalles Bibliográficos
Autores principales: Gok, Muslum, Madrer, Nimrod, Zorbaz, Tamara, Bennett, Estelle R., Greenberg, David, Bennett, David A., Soreq, Hermona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479005/
https://www.ncbi.nlm.nih.gov/pubmed/36117917
http://dx.doi.org/10.3389/fnmol.2022.941467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479005/
https://www.ncbi.nlm.nih.gov/pubmed/36117917
http://dx.doi.org/10.3389/fnmol.2022.941467

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