Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by which CALR mutations cause MPNs has been elucidated, there currently are no clonally selective therapies for CALR-mutant MPNs. To identify unique genetic...

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Detalles Bibliográficos
Autores principales: Jutzi, Jonas S., Marneth, Anna E., Ciboddo, Michele, Guerra-Moreno, Angel, Jiménez-Santos, María José, Kosmidou, Anastasia, Dressman, James W., Liang, Hongyan, Hamel, Rebecca, Lozano, Patricia, Rumi, Elisa, Doench, John G., Gotlib, Jason, Krishnan, Anandi, Elf, Shannon, Al-Shahrour, Fátima, Mullally, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479036/
https://www.ncbi.nlm.nih.gov/pubmed/35763665
http://dx.doi.org/10.1182/blood.2022015629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479036/
https://www.ncbi.nlm.nih.gov/pubmed/35763665
http://dx.doi.org/10.1182/blood.2022015629

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